Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching ... View more
The authors gratefully acknowledge financial support from the EPSRC (Grant No's EP/ H024107/1, EP/I033459/1, EP/J00135X/1, EP/J015156/1, EP/K021966/1, EP/K023004/1, EP/K038885/1, EP/L015668/1 and EP/L023652/1), BBSRC (Grant No. BB/M011267/1), the EC (projects 610730 EVOPROG, 611640 EVOBLISS), ERC (project 670467 SMARTPOM), University of Glasgow for LKAS fellowship, the Honjo Scholarship Foundation and JSPS Grant-in-Aid for Scientific Research (B) . Authors thank Salah Sharabi for designing Arduino shield, Hazuki Kotani for assistance with genome sequencing, Kazufumi Hosoda and Stephanie Connelly for valuable comments and discussions.