Assessing association between protein truncating variants and quantitative traits.
- Publisher: Oxford University Press
Bioinformatics (Oxford, England),
(issn: 1367-4803, eissn: 1367-4811)
Genetics and Population Analysis | Original Papers
Motivation: In sequencing studies of common diseases and quantitative traits, power to test rare and low frequency variants individually is weak. To improve power, a common approach is to combine statistical evidence from several genetic variants in a region. Major chal...