The Combined Inhibitory Effect of the Adenosine A1 and Cannabinoid CB1 Receptors on cAMP Accumulation in the Hippocampus Is Additive and Independent of A1 Receptor Desensitization

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Serpa, André; Correia, Sara; Ribeiro, Joaquim A.; Sebastião, Ana M.; Cascalheira, José F.;
  • Publisher: Hindawi Publishing Corporation
  • Journal: BioMed Research International,volume 2,015 (issn: 2314-6133, eissn: 2314-6141)
  • Related identifiers: pmc: PMC4312621, doi: 10.1155/2015/872684
  • Subject: R | Research Article | Medicine | Article Subject
    mesheuropmc: cardiovascular system

Adenosine A1 and cannabinoid CB1 receptors are highly expressed in hippocampus where they trigger similar transduction pathways. We investigated how the combined acute activation of A1 and CB1 receptors modulates cAMP accumulation in rat hippocampal slices. The CB1 agon... View more
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