Hydrodynamic gene delivery in human skin using a hollow microneedle device

Article English OPEN
Dul, Maria ; Stefanidou, M. ; Porta, P. ; Serve, J. ; O'Mahony, C. ; Malissen, B ; Henri, S ; Levin, Y ; Kochba, E ; Wong, Florence Susan ; Dayan, Colin ; Coulman, Sion ; Birchall, James Caradoc (2017)
  • Publisher: Elsevier
  • Embargo end date: 2017-10-20
  • Related identifiers: doi: 10.1016/j.jconrel.2017.02.028
  • Subject: Genetic vaccine | DNA | Human skin | Microneedles | Gene therapy | Hydrodynamic | RM

Microneedle devices have been proposed as a minimally invasive delivery system for the intradermal administration of nucleic acids, both plasmid DNA (pDNA) and siRNA, to treat localised disease or provide vaccination. Different microneedle types and application methods ... View more
  • References (12)
    12 references, page 1 of 2

    A. Abdul-Wahab, W. Qasim, J.A. McGrath, Gene therapies for inherited skin disorders, Semin Cutan Med Surg. 33(2) (2014) 83-90.

    A.D. Bins, A. Jorritsma, M.C. Wolkers, C.F. Hung, T.C. Wu, T.N. Schumacher, J.B. Haaneen, A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression, Nat Med 11 (2005) 899-904.

    J.C. Birchall, S.A. Coulman, M. Pearton, C. Allender, K. Brain, A. Anstey, C. Gateley, N. Wilke, A. Morrissey, Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles, J. Drug Target, 13(7) (2005) 415-42.

    J.C. Birchall, S.A. Coulman, A. Anstey, C. Gateley, H. Sweetland, A. Gershonowitz, L. Neville, G. Levin, Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation, Int. J Pharm. 312 (1-2) (2006) 15-23.

    B. Bonamassa, L. Hai, D. Liu, Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research. Pharm Res 28(4) (2011) 694-701.

    P. Boukamp, R.T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, N.E. Fusenig, Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line, J. Cell Biol. 106 (1988) 761-771.

    H. Boulaiz, J.A. Marchal, J. Prados, C. Melguizo, A. Aránega, Non-viral and viral vectors for gene therapy, Cell Mol Biol (Noisy-le-grand) 2(51) (2005) 3-22.

    R.M. Brand, P.L. Iversen, Iontophoretic delivery of atelomeric oligonucleotide, Pharm. Res. 13 (1996) 851-854.

    K.E. Broderick, X. Shen, J. Soderholm, F. Lin, J. McCoy, A.S. Khan, J. Yan, M.P. Morrow, A. Patel, G.P. Kobinger, S. Kemmerrer, D.B. Weiner, N.Y. Sardesai, Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device, Mol Ther 3 (2011) 249-255.

    R. Cartier, S.V. Ren, W. Walther, U. Stein, A. Lewis, P.M. Schlag, M. Li, P.A. Furth, In vivo gene transfer by low-volume jet injection, Anal. Biochem. 282 (2000) 262-265.

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