A Simple Three-Step Method for Design and Affinity Testing of New Antisense Peptides: An Example of Erythropoietin

Other literature type, Article English OPEN
Nikola Štambuk; Zoran Manojlović; Petra Turčić; Roko Martinić; Paško Konjevoda; Tin Weitner; Piotr Wardega; Mario Gabričević;
(2014)
  • Publisher: MDPI
  • Journal: International Journal of Molecular Sciences, volume 15, issue 6, pages 9,209-9,223 (issn: 1422-0067, eissn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC4100090, doi: 10.3390/ijms15069209
  • Subject: Chemistry | peptide | modeling | QD1-999 | binding | Article | QH301-705.5 | thermophoresis | fluorescence | spectroscopy | Pharmacy | Biology (General) | erythropoietin | antisense

Antisense peptide technology is a valuable tool for deriving new biologically active molecules and performing peptide–receptor modulation. It is based on the fact that peptides specified by the complementary (antisense) nucleotide sequences often bind to each other with... View more
  • References (50)
    50 references, page 1 of 5

    1. Heal, J.R.; Roberts, G.W.; Raynes, J.G.; Bhakoo, A.; Miller, A.D. Specific interactions between sense and complementary peptides: The basis for the proteomic code. ChemBioChem 2002, 3, 136-151.

    2. Biro, J.C. The proteonomic code: A molecular recognition code for proteins. Theor. Biol. Med. Model. 2007, 4, 1-45.

    3. Blalock, J.E. Genetic origin of protein shape and interaction rules. Nat. Med. 1995, 1, 876-878.

    4. Houra, K.; Turčić, P.; Gabričević, M.; Weitner, T.; Konjevoda, P.; Štambuk, N. Interaction of α-melanocortin and its pentapeptide antisense LVKAT: Effects on hepatoprotection in male CBA mice. Molecules 2011, 16, 7331-7343.

    5. McGuire, K.L.; Holmes, D.S. Role of complementary proteins in autoimmunity: An old idea re-emerges with new twists. Trends Immunol. 2005, 26, 367-372.

    6. Štambuk, N.; Konjevoda, P.; Boban-Blagaić, A.; Pokrić, B. Molecular recognition theory of the complementary (antisense) peptide interactions. Theory Biosci. 2005, 123, 265-275.

    7. Root-Bernstein, R.S. Peptide self-aggregation and peptide complementarity as bases for the evolution of peptide receptors: A review. J. Mol. Recognit. 2005, 18, 40-49.

    8. Molineux, G.; Sinclair, A.M. Biology of erythropoietin. In Erythropoietins, Erythropoietic Factors and Erythropoiesis; Elliott, S.G., Foote, M.A., Molineux, G., Eds.; Birkhäuser Verlag: Basel, Switzerland, 2009; pp. 41-60.

    9. Walsh, G. Biopharmaceuticals: Biochemistry and Biotechnology, 2nd ed.; Wiley: Chichester, UK, 2003; pp. 264-272.

    10. Reichel, C.; Gmeiner, G. Erythropoietin and analogs. In Doping in Sports; Thieme, D., Hemmersbach, P., Eds.; Springer-Verlag: Heildeberg, Germany, 2010; pp. 251-294.

  • Related Organizations (5)
  • Bioentities (1)
    1buy Protein Data Bank
  • Metrics