Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans

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Katherine A. McCulloch ; Yingchuan B. Qi ; Seika Takayanagi-Kiya ; Yishi Jin ; Salvatore J. Cherra III (2017)
  • Publisher: Genetics Society of America
  • Journal: G3: Genes, volume 7, issue 7, pages 2,055-2,063 (issn: 2160-1836, eissn: 2160-1836)
  • Related identifiers: doi: 10.1534/g3.117.042598, pmc: PMC5499116
  • Subject: epilepsy | seizure | major facilitator superfamily domain (MFSD) proteins | locomotion | Investigations | unc-17 | lipid | acetylcholine receptor | QH426-470 | Genetics | sphingosine kinase/sphk-1 | acetylcholine transporter
    mesheuropmc: skin and connective tissue diseases | musculoskeletal diseases | immune system diseases

Acetylcholine (ACh) receptors (AChR) regulate neural circuit activity in multiple contexts. In humans, mutations in ionotropic acetylcholine receptor (iAChR) genes can cause neurological disorders, including myasthenia gravis and epilepsy. In Caenorhabditis elegans, iAC... View more