Assessment of Humoral Immune Responses to Blood-Stage Malaria Antigens following ChAd63-MVA Immunization, Controlled Human Malaria Infection and Natural Exposure

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Sumi Biswas; Prateek Choudhary; Sean C Elias; Kazutoyo Miura; Kathryn H Milne; Simone C de Cassan; Katharine A Collins; Fenella D Halstead; Carly M Bliss; Katie J Ewer; Faith H Osier; Susanne H Hodgson; Christopher J A Duncan; Geraldine A O'Hara; Carole A Long; Adrian V S Hill; Simon J Draper;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 9,issue 9 (issn: 1932-6203, eissn: 1932-6203)
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  • Related identifiers: doi: 10.1371/journal.pone.0107903, pmc: PMC4177865
  • Subject: Humoral Immunity | Research Article | Biology and Life Sciences | Vaccine Development | Vaccines | Medicine | Immunity | Humoral Immune Response | Tropical Diseases | Malaria | Vaccination and Immunization | Recombinant Vaccines | Q | R | Science | Medicine and Health Sciences | Immunology
    mesheuropmc: parasitic diseases

The development of protective vaccines against many difficult infectious pathogens will necessitate the induction of effective antibody responses. Here we assess humoral immune responses against two antigens from the blood-stage merozoite of the Plasmodium falciparum hu... View more