publication . Article . 2009

Use of supplementary phenotype to identify additional rheumatoid arthritis loci in a linkage analysis of 342 UK affected sibling pair families

Trevisan Maurizio; Miller Austin; Kelemen Arpad; Liang Yulan; Tayo Bamidele O; Cooper Richard S;
Open Access
  • Published: 01 Dec 2009 Journal: BMC Medical Genetics, volume 10 (eissn: 1471-2350, Copyright policy)
  • Publisher: Springer Nature
Abstract
<p>Abstract</p> <p>Background</p> <p>Although rheumatoid arthritis has been shown to have moderately strong genetic component, both linked loci identified in linkage analyses and susceptibility variants from association studies are short of adequately accounting for a comprehensive catalogue of the molecular factors underlying this complex disease. The objective of this study was to use supplementary phenotype based on cumulative hazard of rheumatoid arthritis to identify linkage evidence for new and additional rheumatoid arthritis loci in a genome-wide linkage analysis of 342 affected sibling pair families from the United Kingdom.</p> <p>Methods</p> <p>Using pr...
Subjects
free text keywords: Genetics(clinical), Genetics, Locus (genetics), Nuclear family, Biology, Genome-wide association study, Genetic association, Rheumatoid arthritis, medicine.disease, medicine, Human genetics, Sibling, Genetic linkage, Research article, Internal medicine, RC31-1245, QH426-470
Funded by
NIH| NARAC The Genetics of Rheumatoid Arthritis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AR044422-10
  • Funding stream: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
,
NIH| Genetics of Hypertension in Blacks
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL053353-15
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
34 references, page 1 of 3

MacKay, K, Eyre, S, Myerscough, A, Milicic, A, Barton, A, Laval, S, Barrett, J, Lee, D, White, S, John, S, Brown, MA, Bell, J, Silman, A, Ollier, W, Wordsworth, P, Worthington, J. Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom. Arthritis and rheumatism. 2002; 46 (3): 632-639 [OpenAIRE] [PubMed] [DOI]

Seldin, MF, Amos, CI, Ward, R, Gregersen, PK. The genetics revolution and the assault on rheumatoid arthritis. Arthritis and rheumatism. 1999; 42 (6): 1071-1079 [PubMed] [DOI]

Jawaheer, D, Seldin, MF, Amos, CI, Chen, WV, Shigeta, R, Monteiro, J, Kern, M, Criswell, LA, Albani, S, Nelson, JL, Clegg, DO, Pope, R, Schroeder, HW, Bridges, SL, Pisetsky, DS, Ward, R, Kastner, DL, Wilder, RL, Pincus, T, Callahan, LF, Flemming, D, Wener, MH, Gregersen, PK. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. American journal of human genetics. 2001; 68 (4): 927-936 [OpenAIRE] [PubMed] [DOI]

del Junco, D, Luthra, HS, Annegers, JF, Worthington, JW, Kurland, LT. The familial aggregation of rheumatoid arthritis and its relationship to the HLA-DR4 association. American journal of epidemiology. 1984; 119 (5): 813-829 [PubMed]

Thomas, DJ, Young, A, Gorsuch, AN, Bottazzo, GF, Cudworth, AG. Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease. Annals of the rheumatic diseases. 1983; 42 (3): 297-300 [OpenAIRE] [PubMed] [DOI]

Aho, K, Koskenvuo, M, Tuominen, J, Kaprio, J. Occurrence of rheumatoid arthritis in a nationwide series of twins. The Journal of rheumatology. 1986; 13 (5): 899-902 [OpenAIRE] [PubMed]

Lawrence, JS, Valkenburg, HA, Bremner, JM, Ball, J. Rheumatoid factors in families. Annals of the rheumatic diseases. 1970; 29 (3): 269-274 [OpenAIRE] [PubMed] [DOI]

Silman, AJ, MacGregor, AJ, Thomson, W, Holligan, S, Carthy, D, Farhan, A, Ollier, WE. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. British journal of rheumatology. 1993; 32 (10): 903-907 [OpenAIRE] [PubMed] [DOI]

Lynn, AH, Kwoh, CK, Venglish, CM, Aston, CE, Chakravarti, A. Genetic epidemiology of rheumatoid arthritis. American journal of human genetics. 1995; 57 (1): 150-159 [OpenAIRE] [PubMed]

Julia, A, Ballina, J, Canete, JD, Balsa, A, Tornero-Molina, J, Naranjo, A, Alperi-Lopez, M, Erra, A, Pascual-Salcedo, D, Barcelo, P, Camps, J, Marsal, S. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis and rheumatism. 2008; 58 (8): 2275-2286 [OpenAIRE] [PubMed] [DOI]

Hinks, A, Barton, A, Shephard, N, Eyre, S, Bowes, J, Cargill, M, Wang, E, Ke, X, Kennedy, GC, John, S, Worthington, J, Thomson, W. Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. Arthritis and rheumatism. 2009; 60 (1): 258-263 [OpenAIRE] [PubMed] [DOI]

Cui, J, Taylor, KE, Destefano, AL, Criswell, LA, Izmailova, ES, Parker, A, Roubenoff, R, Plenge, RM, Weinblatt, ME, Shadick, NA, Karlson, EW. Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis. Mol Med. 2009; 15 (5-6): 136-143 [OpenAIRE] [PubMed] [DOI]

MacGregor, AJ, Snieder, H, Rigby, AS, Koskenvuo, M, Kaprio, J, Aho, K, Silman, AJ. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis and rheumatism. 2000; 43 (1): 30-37 [OpenAIRE] [PubMed] [DOI]

Amos, CI, Chen, WV, Lee, A, Li, W, Kern, M, Lundsten, R, Batliwalla, F, Wener, M, Remmers, E, Kastner, DA, Criswell, LA, Seldin, MF, Gregersen, PK. High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33. Genes and immunity. 2006; 7 (4): 277-286 [OpenAIRE] [PubMed] [DOI]

John, S, Amos, C, Shephard, N, Chen, W, Butterworth, A, Etzel, C, Jawaheer, D, Seldin, M, Silman, A, Gregersen, P, Worthington, J. Linkage analysis of rheumatoid arthritis in US and UK families reveals interactions between HLA-DRB1 and loci on chromosomes 6q and 16p. Arthritis and rheumatism. 2006; 54 (5): 1482-1490 [OpenAIRE] [PubMed] [DOI]

34 references, page 1 of 3
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