Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.

Article English OPEN
Alexandra J Spencer ; Matthew G Cottingham ; Jennifer A Jenks ; Rhea J Longley ; Stefania Capone ; Stefano Colloca ; Antonella Folgori ; Riccardo Cortese ; Alfredo Nicosia ; Migena Bregu ; Adrian V S Hill
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 9, issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0100538
  • Subject: Q | R | Science | Medicine
    mesheuropmc: complex mixtures

The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4+ T cells, but enhanced CD8+ T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest. In this study we ass... View more
Share - Bookmark