Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.

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Alexandra J Spencer; Matthew G Cottingham; Jennifer A Jenks; Rhea J Longley; Stefania Capone; Stefano Colloca; Antonella Folgori; Riccardo Cortese; Alfredo Nicosia; Migena Bregu; Adrian V S Hill;

The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4+ T cells, but enhanced CD8+ T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest. In this study we ass... View more
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