Capillary electrophoresis as a screening tool for alpha amylase inhibitors in plant extracts

Article, Other literature type English OPEN
Hamdan, Imad I. ; Afifi, Fatima U. (2010)
  • Publisher: Elsevier BV
  • Journal: Saudi Pharmaceutical Journal, volume 18, issue 2, pages 91-95 (issn: 1319-0164)
  • Related identifiers: doi: 10.1016/j.jsps.2010.02.004
  • Subject: Original Article | Pharmaceutical Science | Pharmacology
    mesheuropmc: food and beverages

Capillary electrophoresis (CE) method was developed for screening plant extract for potential alpha amylase (AA) inhibitory activity. The method was validated against a well established UV method. Overall, the proposed method was shown able to detect plants with significant alpha amylase inhibitory activity but not those with rather clinically insignificant activities. Fifty plant species were screened using both the proposed CE method and the UV method and seven plant species were found to possess significant AA inhibitory activities. Two plant species were proved to have alpha amylase inhibitory activity for the first time.
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