Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

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Warmerdam, Daniel O.; van den Berg, Jeroen; Medema, Rene H.;
  • Publisher: Elsevier
  • Journal: Cell Reports,volume 14,issue 11,pages2,519-2,527 (issn: 2211-1247)
  • Related identifiers: doi: 10.1016/j.celrep.2016.02.048
  • Subject: Biology (General) | QH301-705.5

rDNA repeats constitute the most heavily transcribed region in the human genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that the repeats are a liability to the genomic integrity of a cell. However, little is known about how cells ... View more
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