Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

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Warmerdam, Daniel O.; van den Berg, Jeroen; Medema, Rene H.;

rDNA repeats constitute the most heavily transcribed region in the human genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that the repeats are a liability to the genomic integrity of a cell. However, little is known about how cells ... View more
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