Genetic diversity is a predictor of mortality in humans

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Bihlmeyer, Nathan A ; Brody, Jennifer A ; Smith, Albert Vernon ; Lunetta, Kathryn L ; Nalls, Mike ; Smith, Jennifer A ; Tanaka, Toshiko ; Davies, Gail ; Yu, Lei ; Mirza, Saira Saeed ; Teumer, Alexander ; Coresh, Josef ; Pankow, James S ; Franceschini, Nora ; Scaria, Anish ; Oshima, Junko ; Psaty, Bruce M ; Gudnason, Vilmundur ; Eiriksdottir, Gudny ; Harris, Tamara B ; Li, Hanyue ; Karasik, David ; Kiel, Douglas P ; Garcia, Melissa ; Liu, Yongmei ; Faul, Jessica D ; Kardia, Sharon LR ; Zhao, Wei ; Ferrucci, Luigi ; Allerhand, Michael ... view all 52 authors (2014)

Background: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypoth... View more
  • References (16)
    16 references, page 1 of 2

    1. Online Mendelian Inheritance in Man []

    2. Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, Manolio TA: Potential etiologic and functional implications of genomewide association loci for human diseases and traits. Proc Natl Acad Sci U S A 2009, 106:9362-9367.

    3. Mitton JB, Grant MC: Associations among protein heterozygosity, growth rate, and developmental homeostasis. Annu Rev Ecol Syst 1984, 15:479-499.

    4. Alibert P, Renaud S, Dod B, Bonhomme F, Auffray JC: Fluctuating asymmetry in the Mus musculus hybrid zone: a heterotic effect in disrupted co-adapted genomes. Proc Biol Sci 1994, 258:53-59.

    5. Roberts SC, Little AC, Gosling LM, Perrett DI, Carter V, Jones BC, Penton-Voak I, Petrie M: MHC-heterozygosity and human facial attractiveness. Evol Hum Behav 2005, 26:213-226.

    6. Coetzee V, Barrett L, Greeff JM, Henzi SP, Perrett DI, Wadee AA: Common HLA alleles associated with health, but Not with facial attractiveness. PLoS One 2007, 2:e640.

    7. Campbell H, Carothers AD, Rudan I, Hayward C, Biloglav Z, Barac L, Pericic M, Janicijevic B, Smolej-Narancic N, Polasek O, Kolcic I, Weber JL, Hastie ND, Rudan P, Wright AF: Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits. Hum Mol Genet 2007, 16:233-241.

    8. Takata H, Ishii T, Suzuki M, Sekiguchi S, Iri H: Influence of major histocompatibility complex region genes on human longevity among okinawan-japanese centenarians and nonagenarians. Lancet 1987, 330:824-826.

    9. Lie HC, Simmons LW, Rhodes G: Does genetic diversity predict health in humans? PLoS One 2009, 4:e6391.

    10. Piertney SB, Oliver MK: The evolutionary ecology of the major histocompatibility complex. Heredity 2005, 96:7-21.

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