Immunohistochemical Studies of the Kynurenine Pathway in Morphea

Article English OPEN
Rowland Noakes ; Nick Mellick (2013)
  • Publisher: SAGE Publishing
  • Journal: International Journal of Tryptophan Research, volume 6, pages 97-102 (issn: 1178-6469, eissn: 1178-6469)
  • Related identifiers: pmc: PMC3873171, doi: 10.4137/IJTR.S13371
  • Subject: indoleamine 2 | QP1-981 | Morphea | quinolinic acid | Physiology | Original Research | 3-dioxygenase

Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.
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