publication . Article . Other literature type . 2017

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.

Sophia R. Lieberman; Vanessa M. Hubbard-Lucey; Jill M. Marinis; Ken Cadwell; M. Zahidunnabi Dewan; Chen Liu; Luis E. Gomez; Philip A. Harris; Marcel R.M. van den Brink; Marcel R.M. van den Brink; ...
Open Access
  • Published: 31 Oct 2017 Journal: Journal of Experimental Medicine, volume 214, pages 3,687-3,705 (issn: 0022-1007, eissn: 1540-9538, Copyright policy)
  • Publisher: Rockefeller University Press
Abstract
Matsuzawa-Ishimoto et al. show that autophagy gene ATG16L1, which is associated with inflammatory diseases of the gastrointestinal tract, is essential for preventing necroptotic cell death and loss of Paneth cells in the intestinal epithelium.
Subjects
Medical Subject Headings: digestive system
free text keywords: Immunology, Immunology and Allergy, Research Articles, Article, 319, RIPK1, ATG16L1, Programmed cell death, Cancer research, Intestinal mucosa, Autophagy, Medicine, business.industry, business, Tumor necrosis factor alpha, Necroptosis, Intestinal epithelium
Funded by
NIH| Characterization of a commensal enteric virus
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK093668-08
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI080455-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| The role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01HL123340-01A1
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Strategies to enhance immune reconstitution after bone marrow transplant
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL069929-12
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
60 references, page 1 of 4

Adolph T.E., Tomczak M.F., Niederreiter L., Ko H.J., Böck J., Martinez-Naves E., Glickman J.N., Tschurtschenthaler M., Hartwig J., Hosomi S., 2013 Paneth cells as a site of origin for intestinal inflammation. Nature.503:272–276. 10.1038/nature12599 24089213 [OpenAIRE] [PubMed] [DOI]

Benjamin J.L., Sumpter R.Jr., Levine B., and Hooper L.V.2013 Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe.13:723–734. 10.1016/j.chom.2013.05.004 23768496 [OpenAIRE] [PubMed] [DOI]

Berry D.L., and Baehrecke E.H.2007 Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell.131:1137–1148. 10.1016/j.cell.2007.10.048 18083103 [OpenAIRE] [PubMed] [DOI]

Blaser H., Dostert C., Mak T.W., and Brenner D.2016 TNF and ROS crosstalk in inflammation. Trends Cell Biol.26:249–261. 10.1016/j.tcb.2015.12.002 26791157 [OpenAIRE] [PubMed] [DOI]

Blazar B.R., Murphy W.J., and Abedi M.2012 Advances in graft-versus-host disease biology and therapy. Nat. Rev. Immunol.12:443–458. 10.1038/nri3212 22576252 [OpenAIRE] [PubMed] [DOI]

Cadwell K.2015 The virome in host health and disease. Immunity.42:805–813. 10.1016/j.immuni.2015.05.003 25992857 [OpenAIRE] [PubMed] [DOI]

Cadwell K.2016 Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat. Rev. Immunol.16:661–675. 10.1038/nri.2016.100 27694913 [OpenAIRE] [PubMed] [DOI]

Cadwell K., Liu J.Y., Brown S.L., Miyoshi H., Loh J., Lennerz J.K., Kishi C., Kc W., Carrero J.A., Hunt S., 2008 A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature.456:259–263. 10.1038/nature07416 18849966 [OpenAIRE] [PubMed] [DOI]

Cadwell K., Patel K.K., Maloney N.S., Liu T.C., Ng A.C., Storer C.E., Head R.D., Xavier R., Stappenbeck T.S., and Virgin H.W.2010 Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1 phenotypes in intestine. Cell.141:1135–1145. 10.1016/j.cell.2010.05.009 20602997 [OpenAIRE] [PubMed] [DOI]

Chen S.Y., Chiu L.Y., Maa M.C., Wang J.S., Chien C.L., and Lin W.W.2011 zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy.7:217–228. 10.4161/auto.7.2.14212 21127402 [OpenAIRE] [PubMed] [DOI]

Conway K.L., Kuballa P., Song J.H., Patel K.K., Castoreno A.B., Yilmaz O.H., Jijon H.B., Zhang M., Aldrich L.N., Villablanca E.J., 2013 Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology.145:1347–1357. 10.1053/j.gastro.2013.08.035 23973919 [OpenAIRE] [PubMed] [DOI]

Cooke K.R., Krenger W., Hill G., Martin T.R., Kobzik L., Brewer J., Simmons R., Crawford J.M., van den Brink M.R., and Ferrara J.L.1998 Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood.92:2571–2580.9746799 [PubMed]

Degterev A., Huang Z., Boyce M., Li Y., Jagtap P., Mizushima N., Cuny G.D., Mitchison T.J., Moskowitz M.A., and Yuan J.2005 Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol.1:112–119. 10.1038/nchembio711 16408008 [OpenAIRE] [PubMed] [DOI]

Diamanti M.A., Gupta J., Bennecke M., De Oliveira T., Ramakrishnan M., Braczynski A.K., Richter B., Beli P., Hu Y., Saleh M., 2017 IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J. Exp. Med.214:423–437. 10.1084/jem.20161867 28082356 [OpenAIRE] [PubMed] [DOI]

Fang H., Tan M., Xia M., Wang L., and Jiang X.2013 Norovirus P particle efficiently elicits innate, humoral and cellular immunity. PLoS One.8:e63269 10.1371/journal.pone.0063269 23638188 [OpenAIRE] [PubMed] [DOI]

60 references, page 1 of 4
Any information missing or wrong?Report an Issue