Charge neutralization as the major factor for the assembly of nucleocapsid-like particles from C-terminal truncated hepatitis C virus core protein

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Theo Luiz Ferraz de Souza; Sheila Maria Barbosa de Lima; Vanessa L. de Azevedo Braga; David S. Peabody; Davis Fernandes Ferreira; M. Lucia Bianconi; Andre Marco de Oliveira Gomes; Jerson Lima Silva; Andréa Cheble de Oliveira;
  • Publisher: PeerJ Inc.
  • Journal: PeerJ,volume 4 (issn: 2167-8359, eissn: 2167-8359)
  • Related identifiers: pmc: PMC5111903, doi: 10.7717/peerj.2670
  • Subject: R | HCV core protein | Virology | Biochemistry | Capsid assembly | Fluorescence spectroscopy | Structural biology | Medicine | Circular dichroism | Biophysics

Background Hepatitis C virus (HCV) core protein, in addition to its structural role to form the nucleocapsid assembly, plays a critical role in HCV pathogenesis by interfering in several cellular processes, including microRNA and mRNA homeostasis. The C-terminal truncat... View more
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