publication . Article . 2016

A deletion in the canine POMC gene is associated with weight and appetite in obesity prone Labrador retriever dogs

Raffan, Eleanor; Dennis, Rowena J.; O’Donovan, Conor J.; Becker, Julia M.; Scott, Robert A.; Smith, Stephen P.; Withers, David J.; Wood, Claire J.; Conci, Elena; Clements, Dylan N.; ...
Open Access English
  • Published: 10 May 2016 Journal: volume 23, issue 5, pages 893-900issn: 1550-4131, eissn: 1932-7420, Copyright policy
  • Publisher: Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Abstract
Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant ...
Subjects
free text keywords: Molecular Biology, Endokrinologi och diabetes, Cell Biology, Cell- och molekylärbiologi, Short Article, Physiology, Cell and Molecular Biology, Endocrinology and Diabetes
Funded by
WT| Insulin Resistance: Lessons from Extreme Phenotypes.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 095515
  • Funding stream: Physiology in Health and Disease ; Physiological Sciences
,
WT| Institute of Metabolic Science.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 100574
  • Funding stream: Physiology in Health and Disease ; Physiological Sciences
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publication . Article . 2016

A deletion in the canine POMC gene is associated with weight and appetite in obesity prone Labrador retriever dogs

Raffan, Eleanor; Dennis, Rowena J.; O’Donovan, Conor J.; Becker, Julia M.; Scott, Robert A.; Smith, Stephen P.; Withers, David J.; Wood, Claire J.; Conci, Elena; Clements, Dylan N.; ...