Ecto-5'-nucleotidase: a candidate virulence factor in Streptococcus sanguinis experimental endocarditis.

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Jingyuan Fan; Yongshu Zhang; Olivia N Chuang-Smith; Kristi L Frank; Brian D Guenther; Marissa Kern; Patrick M Schlievert; Mark C Herzberg;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0038059, pmc: PMC3369921
  • Subject: Oral Medicine | Research Article | Biology | Molecular Cell Biology | Dentistry | Infectious Diseases | Microbiology | Medicine | Bacterial Pathogens | Platelets | Infectious Disease Modeling | Streptococci | Bacterial Diseases | Q | Hematology | Oral Diseases | R | Model Organisms | Biochemistry | Science | Streptococcal Infections | Immunology

Streptococcus sanguinis is the most common cause of infective endocarditis (IE). Since the molecular basis of virulence of this oral commensal bacterium remains unclear, we searched the genome of S. sanguinis for previously unidentified virulence factors. We identified ... View more
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