A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

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Booth, Jonathan ; Alexandru-Crivac, Christina-Nicoleta ; Rickaby, Kirstie A. ; Nneoyiegbe, Ada F. ; Umeobika, Ugochukwu ; McEwan, Andrew R. ; Trembleau, Laurent ; Jaspars, Marcel ; Houssen, Wael E. ; Shalashilin, Dmitrii V. (2017)

An in silico computational technique for predicting peptide sequences that can be cyclized by cyanobactin macrocyclases, e.g., PatGmac, is reported. We demonstrate that the propensity for PatGmac-mediated cyclization correlates strongly with the free energy of the so-ca... View more
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