Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease.

Article English OPEN
Franklin R Toapanta ; Paula J Bernal ; Stephanie Fresnay ; Laurence S Magder ; Thomas C Darton ; Claire Jones ; Claire S Waddington ; Christoph J Blohmke ; Brian Angus ; Myron M Levine ; Andrew J Pollard ; Marcelo B Sztein (2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Neglected Tropical Diseases, volume 10, issue 6 (issn: 1935-2727, eissn: 1935-2735)
  • Related identifiers: doi: 10.1371/journal.pntd.0004766, pmc: PMC4907489
  • Subject: Immune System Proteins | Bacteria | Infectious Diseases | White Blood Cells | Molecular Biology Techniques | Antibodies | Immunology | Phosphorylation | Cellular Types | Biology and Life Sciences | Blood Cells | Physiology | Animal Cells | Bacterial Diseases | Public aspects of medicine | Organisms | Fevers | Molecular Biology | Microbial Pathogens | Research Article | Diagnostic Medicine | Typhoid | Signs and Symptoms | Pathology and Laboratory Medicine | Integrins | Salmonella | Pathogens | Antibody-Producing Cells | Cell Adhesion | Proteins | Immune Physiology | Research and Analysis Methods | Microbiology | Immune Cells | Bacterial Pathogens | Post-Translational Modification | Salmonella Typhi | Medical Microbiology | RC955-962 | Cell Biology | B Cells | RA1-1270 | Cellular Structures and Organelles | Biochemistry | Enterobacteriaceae | Medicine and Health Sciences | Arctic medicine. Tropical medicine | Extracellular Matrix | Cloning

A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 104 CFU of Salmonella resulted in 65% of participants developing typhoid fever (referred here as typhoid diagnosis -TD-) 6–... View more