Immunosuppressive therapy in non-infections uveitis and retinovasculitis

Article Russian OPEN
E. A. Drozdova (2014)
  • Publisher: Ophthalmology Publishing Group
  • Journal: Oftalʹmologiâ (issn: 1816-5095, eissn: 2500-0845)
  • Related identifiers: doi: 10.18008/1816-5095-2012-2-58-61
  • Subject: immunosuppressive agents | RE1-994 | retinovasculitis | Ophthalmology | uveitis

<p><strong>Purpose</strong>: to evaluate the efficacy and safety of the immunosuppressive therapy for severe forms of non-infections uveitis and retinovasculitis.<br /><strong>Methods</strong>: 107 patients (62 males and 45 females aged 9 to 54 years) who received low dose methotrexate — 7.5-20 mg once a week (n=79) cyclosporine A 3.5-5.0 mg/kg/d (n=21) with prednisone or other antimetabolites and local corticosteroid therapy for severe forms of inflammatory eye diseases.<br /><strong>Results</strong>: the efficacy of methotrexate as monotherapy was 51.8% of patients with chronic uveitis. Control of acute inflammation was achived in 71.1% patients, who received methotrexate in combination with prednisolone. Cyclosporine A was more effective in controlling inflammatory of the eye: remission of uveitis was achived in 85.7% in combination with glucocorticoids. No significant side effects have been noted.<br /><strong>Conclusion</strong>: Methotrexate and cyclosporine A with low dose of prednisolone are well tolerated immunosuppressive agents and<br />rather effective in the treatment of non-infectious uveitis and retinovasculitis that fails to respond to conventional steroid treatment.</p>
Share - Bookmark