The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers

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Monzón-Casanova, Elisa; Screen, Michael; Díaz-Muñoz, Manuel D; Coulson, Richard MR; Bell, Sarah Elizabeth; Lamers, Greta; Solimena, Michele; Smith, Christopher; Turner, Martin;

Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from helper T cells, ... View more
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