The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers

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Monzón-Casanova, Elisa ; Screen, Michael ; Díaz-Muñoz, Manuel D. ; Coulson, Richard M. R. ; Bell, Sarah E. ; Lamers, Greta ; Solimena, Michele ; Smith, Christopher W.J. ; Turner, Martin (2018)
  • Publisher: Nature Immunology
  • Journal: Nature immunology, volume 19, issue 3, pages 267-278 (issn: 1529-2908, eissn: 1529-2916)
  • Related identifiers: doi: 10.17863/CAM.26421, doi: 10.1038/s41590-017-0035-5, pmc: PMC5842895
  • Subject: dark zone | antibody affinity maturation | Alternative splicing | germinal centre | Polypyrimidine Track Binding Proteins | cell cycle proliferation | light zone | RNA Binding Proteins | Article | iCLIP

Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from helper T cells, ... View more
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