Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group

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A Alipour ; S Shojaee ; M Mohebali ; M Tehranidoost ; F Abdi Masoleh ; H Keshavarz (2011)
  • Publisher: Tehran University of Medical Sciences
  • Journal: Iranian Journal of Parasitology, volume 6, issue 2, pages 31-37 (issn: 1735-7020, eissn: 2008-238X)
  • Related identifiers: pmc: PMC3279881
  • Subject: Original Article | ELISA | RC109-216 | Iran | Infectious and parasitic diseases | Schizophrenia | Toxoplasma Gondii
    mesheuropmc: behavioral disciplines and activities | parasitic diseases | mental disorders

Background: Schizophrenia is a serious, chronic, and often debilitating neuropsychiatric disor­der. Its causes are still poorly understood. Besides genetic and non-genetic (environmental) fac­tors are thought to be important as the cause of the structural and functional deficits that character­ize schizophrenia. This study aimed to compare Toxoplasma gondii infection between schizo­phrenia patients and non-schizophrenia individuals as control group.Methods: A case-control study was designed in Tehran, Iran during 2009-2010. Sixty-two pa­tients with schizophrenia and 62 non-schizophrenia volunteers were selected. To ascertain a possible relationship between T. gondii infection and schizophrenia, anti-Toxoplasma IgG antibodies were detected by indirect-ELISA. Data were statistically analyzed by chi- square at a confidence level of 99%.Results: The sero-positivity rate among patients with schizophrenia (67.7%) was significantly higher than control group (37.1) (P <0. 01).Conclusion: A significant correlation between Toxoplasma infection and schizophrenia might be ex­pected.
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