A QM/MM–Based Computational Investigation on the Catalytic Mechanism of Saccharopine Reductase

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Joel N., Almasi; Eric A.C., Bushnell; Gauld, James W.;
(2011)

Saccharopine reductase from Magnaporthe grisea, an NADPH-containing enzyme in the α-aminoadipate pathway, catalyses the formation of saccharopine, a precursor to L-lysine, from the substrates glutamate and α-aminoadipate-δ-semialdehyde. Its catalytic mechanism has been ... View more
  • References (33)
    33 references, page 1 of 4

    Vashishtha, A.K.; West, A.H.; Cook, P.F. Chemical mechanism of saccharopine reductase from saccharomyces cerevisiae. Biochemistry 2009, 48, 5899-5907.

    3. Xu, H.Y.; Andi, B.; Qian, J.H.; West, A.H.; Cook, P.F. The alpha-aminoadipate pathway for lysine biosynthesis in fungi. Cell Biochem. Biophys. 2006, 46, 43-64.

    4. Johansson, E.; Steffens, J.J.; Lindqvist, Y.; Schneider, G. Crystal structure of saccharopine reductase from magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis. Structure 2000, 8, 1037-1047.

    5. Talbot, N.J. Having a blast: Exploring the pathogenicity of magnaporthe grisea. Trends Microbiol. 1995, 3, 9-16.

    6. Ribot, C.; Hirsch, J.; Batzergue, S.; Tharreau, D.; Notteghem, J.L.; Lebrun, M.H.; Morel, J.B. Susceptibility of rice to the blast fungus, magnaporthe grisea. J. Plant Physiol. 2008, 165, 114-124.

    7. Erdtman, E.; Bushnell, E.A.C.; Gauld, J.W.; Eriksson, L.A. Computational studies on Schiff-base formation: Implications for the catalytic mechanism of porphobilinogen synthase. Comput. Theory Chem. 2011, 963, 479-489.

    8. Kaya, I.; Dogan, F.; Bilici, A. Schiff base-substituted polyphenol: Synthesis, characterisation and non-isothermal degradation kinetics. Polym. Int. 2009, 58, 570-578.

    9. Lochee, Y.; Jhurry, D.; Bhaw-Luximon, A.; Kalangos, A. Biodegradable poly(ester-ether)s: Ring-opening polymerization of d,l-3-methyl-1,4-dioxan-2-one using various initiator systems. Polym. Int. 2010, 59, 1310-1318.

    10. Godoy-Alcantar, C.; Yatsimirsky, A.K.; Lehn, J.M. Structure-stability correlations for imine formation in aqueous solution. J. Phys. Org. Chem. 2005, 18, 979-985.

    11. Ilieva, S.; Cheshmedzhieva, D.; Tasheva, D. The origin of diastereoselectivity in the michael addition reaction: A computational study of the interaction between ch-acidic Schiff base and alpha,beta-unsaturated ketones. Tetrahedron 2010, 66, 5168-5172.

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