A QM/MM–Based Computational Investigation on the Catalytic Mechanism of Saccharopine Reductase

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Joel N., Almasi; Eric A.C., Bushnell; Gauld, James W.;

Saccharopine reductase from Magnaporthe grisea, an NADPH-containing enzyme in the α-aminoadipate pathway, catalyses the formation of saccharopine, a precursor to L-lysine, from the substrates glutamate and α-aminoadipate-δ-semialdehyde. Its catalytic mechanism has been ... View more
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