Cryopreservation-related loss of antigen-specific IFNγ producing CD4+ T-cells can skew immunogenicity data in vaccine trials: Lessons from a malaria vaccine trial substudy

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Ford, Tom; Wenden, Claire; Mbekeani, Alison; Dally, Len; Cox, Josephine H.; Morin, Merribeth; Winstone, Nicola; Hill, Adrian V.S.; Gilmour, Jill; Ewer, Katie J.;

Ex vivo functional immunoassays such as ELISpot and intracellular cytokine staining (ICS) by flow cytometry are crucial tools in vaccine development both in the identification of novel immunogenic targets and in the immunological assessment of samples from clinical tria... View more
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