Subject: CSP | Immunology and Microbiology(all) | Infectious Diseases | Malaria | Article | Cryopreservation | ChAd63 | veterinary(all) | Molecular Medicine | MVA | TRAP | PBMC | Public Health, Environmental and Occupational Health
Ex vivo functional immunoassays such as ELISpot and intracellular cytokine staining (ICS) by flow cytometry are crucial tools in vaccine development both in the identification of novel immunogenic targets and in the immunological assessment of samples from clinical tria... View more
Boaz, M.J., Hayes, P., Tarragona, T., Seamons, L., Cooper, A., Birungi, J.. Concordant proficiency in measurement of T-cell immunity in human immunodeficiency virus vaccine clinical trials by peripheral blood mononuclear cell and enzyme-linked immunospot assays in laboratories from three continents. Clin Vacc Immunol. 2009; 16: 147-155
Njai, H.F., Gombe, B., Khamis, T., Birungi, J., Ruzagira, E., Admassu, D.. Setting up a standardized peripheral blood mononuclear cells processing laboratory to support multi-center HIV/AIDS vaccine and intervention trials. Labmedicine. 2011; 42: 711-718
10 Agency EM. Reflection paper for laboratories that perform the analysis or evaluation of clinical trial samples. Reflection paper for laboratories that perform the analysis or evaluation of clinical trial samples. London; 2012.