Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

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Orlando, Giulia; Law, Philip J; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hanninen, Ulrika; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Kaprio, Jaakko; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Jarvinen, Heikki J; Renkonen-Sinisalo, Laura; Lepisto, Anna; Bohm, Jan; Meklin, Jukka-Pekka; Al-Tassan, Nada A.; Palles, Claire; Martin, Lynn; Barclay, Ella; Tenesa, Albert; ... view all 57 authors
(2016)
  • Publisher: Oxford University Press
  • Journal: volume 25,issue 11,pages2,349-2,359issn: 0964-6906, eissn: 1460-2083
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1093/hmg/ddw087., doi: 10.1093/hmg/ddw087, pmc: PMC5081051
  • Subject: RC0254 | 3122 Cancers | METAANALYSIS | SUSCEPTIBILITY LOCI | 3126 Surgery, anesthesiology, intensive care, radiology | FUNCTIONAL VARIATION | COHORT PROFILE | INTESTINAL INFLAMMATION | VARIANTS | 3121 Internal medicine | Terveystiede - Health care science | CROHNS-DISEASE | 3111 Biomedicine | IMPUTATION | BIRTH COHORT | GENOME-WIDE ASSOCIATION | Syöpätaudit - Cancers | Association Studies Articles
    mesheuropmc: digestive system diseases

To identify new risk loci for colorectal cancer (CRC), we conducted a meta-analysis of seven genome-wide association studies (GWAS) with independent replication, totalling 13 656 CRC cases and 21 667 controls of European ancestry. The combined analysis identified a new ... View more