Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

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Orlando, Giulia ; Law, Philip J ; Palin, Kimmo ; Tuupanen, Sari ; Gylfe, Alexandra ; Hanninen, Ulrika ; Cajuso, Tatiana ; Tanskanen, Tomas ; Kondelin, Johanna ; Kaasinen, Eevi ; Sarin, Antti-Pekka ; Kaprio, Jaakko ; Eriksson, Johan G. ; Rissanen, Harri ; Knekt, Paul ; Pukkala, Eero ; Jousilahti, Pekka ; Salomaa, Veikko ; Ripatti, Samuli ; Palotie, Aarno ; Jarvinen, Heikki J ; Renkonen-Sinisalo, Laura ; Lepisto, Anna ; Bohm, Jan ; Meklin, Jukka-Pekka ; Al-Tassan, Nada A. ; Palles, Claire ; Martin, Lynn ; Barclay, Ella ; Tenesa, Albert ... view all 57 authors (2016)
  • Publisher: Oxford University Press
  • Journal: volume 25, issue 11, pages 2,349-2,359 (issn: 0964-6906, eissn: 1460-2083)
  • Related identifiers: doi: 10.1093/hmg/ddw087., doi: 10.1093/hmg/ddw087, pmc: PMC5081051
  • Subject: 3122 Cancers | RC0254 | METAANALYSIS | SUSCEPTIBILITY LOCI | 3126 Surgery, anesthesiology, intensive care, radiology | FUNCTIONAL VARIATION | fi=Terveystiede | en=Health care science| | COHORT PROFILE | INTESTINAL INFLAMMATION | VARIANTS | 3121 Internal medicine | CROHNS-DISEASE | 3111 Biomedicine | IMPUTATION | BIRTH COHORT | GENOME-WIDE ASSOCIATION | fi=Syöpätaudit | en=Cancers| | Association Studies Articles
    mesheuropmc: digestive system diseases

To identify new risk loci for colorectal cancer (CRC), we conducted a meta-analysis of seven genome-wide association studies (GWAS) with independent replication, totalling 13 656 CRC cases and 21 667 controls of European ancestry. The combined analysis identified a new ... View more