5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia

Article English OPEN
Grandjenette, Cindy ; Schnekenburger, Michael ; Karius, Tommy ; Ghelfi, Jenny ; Gaigneaux, Anthoula ; Henry, Estelle ; Dicato, Mario ; Diederich, Marc (2014)
  • Publisher: Elsevier BV
  • Journal: Neoplasia, volume 16, issue 6, pages 511-528 (issn: 1476-5586)
  • Related identifiers: doi: 10.1016/j.neo.2014.05.009
  • Subject: RC254-282 | Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Increased proliferation rates as well as resistance to apoptosis are considered major obstacles for the treatment of patients with chronic myelogenous leukemia (CML), thus highlighting the need for novel therapeutic approaches. Since senescence has been recognized as a ... View more
Share - Bookmark