Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: A large-scale biomarker-characterized monocenter cohort study (ClinAD)

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Epelbaum , Stéphane ; Teichmann , Marc ; Samri , Dalila ; Nogueira , Marcel , ; Hampel , Harald ; Lamari , Foudil ; Dubois , Bruno ; Michon , Agnès (2017)
  • Publisher: HAL CCSD
  • Related identifiers: doi: 10.1016/j.jalz.2016.12.014
  • Subject: Alzheimer's disease | Neurodegenerative diseases | Assessment of memory disorders | [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | Dementia

International audience; Introduction: The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? Methods: We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts , blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, " subjective cognitive decline, " or depression. Results: The FCSRT distinguished typical AD from all other conditions with a sensitivity of 100% and a specificity of 75%. Non-AD neurodegenerative diseases with positive AD CSF biomarkers (" atypical AD ") did not have lower FCSRT scores than those with negative biomarkers. Discussion: The FCSRT is a reliable tool for diagnosing typical AD among various neurodegener-ative diseases. At an individual level, however, its specificity is not absolute. Our findings also widen the spectrum of atypical AD to multiple neurodegenerative conditions.
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