Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Article, Other literature type English OPEN
Matthew R. Broadus; Tony W. Chen; Leif R. Neitzel; Victoria H. Ng; Jeanne N. Jodoin; Laura A. Lee; Adrian Salic; David J. Robbins; Anthony J. Capobianco; James G. Patton; Stacey S. Huppert; Ethan Lee;
(2016)

Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We sh... View more
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