publication . Article . 2008

Porcine circovirus type 2 induces the activation of nuclear factor kappa B by IκBα degradation

Jimmy Kwang; Jin Wang; Li Wei; Jue Liu; Bing Yang; Yongqing Li; Lei Shi;
Open Access English
  • Published: 01 Aug 2008 Journal: Virology, issue 1, pages 177-184 (issn: 00426822, Copyright policy)
  • Publisher: Elsevier Inc.
Abstract
The transcription factor NF-kappaB is commonly activated upon virus infection and a key player in the induction and regulation of the host immune response. The present study demonstrated for the first time that porcine circovirus type 2 (PCV2), which is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome, can activate NF-kappaB in PCV2-infected PK15 cells. In PCV2-infected cells, NF-kappaB was activated concomitantly with viral replication, which was characterized by increased DNA binding activity, translocation of NF-kappaB p65 from the cytoplasm to the nucleus, as well as degradation and phosphorylation of Ikapp...
Subjects
Medical Subject Headings: animal diseasesvirus diseases
free text keywords: PCV2, NF-κB, IκB family, Caspase-3 activity, PK15 cells, Virology, Molecular biology, Transcription factor, Virus, Cell culture, Apoptosis, IκBα, Biology, Viral replication, chemistry.chemical_compound, chemistry, Porcine circovirus, biology.organism_classification
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