publication . Article . 2008

Porcine circovirus type 2 induces the activation of nuclear factor kappa B by IκBα degradation

Name: Porcine circovirus type 2 induces the activation of nuclear factor kappa B by IκBα degradation
Keywords: PCV2, NF-κB, IκB family, Caspase-3 activity, PK15 cells, Virology

Jimmy Kwang; Jin Wang; Li Wei; Jue Liu; Bing Yang; Yongqing Li; Lei Shi;

Open Access English

Published: 01 Aug 2008 Journal: Virology, issue 1, pages 177-184 (issn: 00426822,

Publisher: Elsevier Inc.

Summary
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Abstract

The transcription factor NF-kappaB is commonly activated upon virus infection and a key player in the induction and regulation of the host immune response. The present study demonstrated for the first time that porcine circovirus type 2 (PCV2), which is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome, can activate NF-kappaB in PCV2-infected PK15 cells. In PCV2-infected cells, NF-kappaB was activated concomitantly with viral replication, which was characterized by increased DNA binding activity, translocation of NF-kappaB p65 from the cytoplasm to the nucleus, as well as degradation and phosphorylation of Ikapp...

doi: 10.1016/j.virol.2008.05.013

Subjects

Medical Subject Headings: animal diseasesvirus diseases

free text keywords: PCV2, NF-κB, IκB family, Caspase-3 activity, PK15 cells, Virology, Molecular biology, Transcription factor, Virus, Cell culture, Apoptosis, IκBα, Biology, Viral replication, chemistry.chemical_compound, chemistry, Porcine circovirus, biology.organism_classification

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