Bacterial protease uses distinct thermodynamic signatures for substrate recognition

Article English OPEN
Bezerra, Gustavo Arruda; Ohara-Nemoto, Yuko; Cornaciu, Irina; Fedosyuk, Sofiya; Hoffmann, Guillaume; Round, Adam; Márquez, José A.; Nemoto, Takayuki K.; Djinović-Carugo, Kristina;
(2017)

Porphyromonas gingivalis and Porphyromonas endodontalis are important bacteria related to periodontitis, the most common chronic inflammatory disease in humans worldwide. Its comorbidity with systemic diseases, such as type 2 diabetes, oral cancers and cardiovascular di... View more
  • References (67)
    67 references, page 1 of 7

    1. Eke, P. I. et al. Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012. J. Periodontol. 86, 611-622 (2015).

    2. Batchelor, P. Is periodontal disease a public health problem? Br. Dent. J. 217, 405-409 (2014).

    3. Chee, B., Park, B. & Bartold, P. M. Periodontitis and type II diabetes: a two-way relationship. Int. J. Evid. Based Healthc. 11, 317-329 (2013).

    4. Hajishengallis, G., Darveau, R. P. & Curtis, M. A. eTh keystone-pathogen hypothesis. Nat. Rev. Microbiol. 10, 717-725 (2012).

    5. Lombardo Bedran, T. B. et al. Porphyromonas endodontalis in chronic periodontitis: a clinical and microbiological cross-sectional study. J. Oral Microbiol. 4, 10123 (2012).

    6. Wang, J. & Jia, H. Metagenome-wide association studies: fine-mining the microbiome. Nat. Rev. Microbiol. 14, 508-522 (2016).

    7. Lalla, E. & Papapanou, P. N. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat. Rev. Endocrinol. 7, 738-748 (2011).

    8. Lundberg, K., Wegner, N., Yucel-Lindberg, T. & Venables, P. J. Periodontitis in RA-the citrullinated enolase connection. Nat. Rev. Rheumatol. 6, 727-730 (2010).

    9. Javed, F. & Warnakulasuriya, S. Is there a relationship between periodontal disease and oral cancer? A systematic review of currently available evidence. Crit. Rev. Oncol. Hematol. 97, 197-205 (2015).

    10. Ha, N. H. et al. Prolonged and repetitive exposure to Porphyromonas gingivalis increases aggressiveness of oral cancer cells by promoting acquisition of cancer stem cell properties. Tumour Biol. 36, 9947-9960 (2015).

  • Similar Research Results (2)
  • Metrics
    No metrics available
Share - Bookmark