The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

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Czimmerer, Zsolt ; Daniel, Bence ; Horvath, Attila ; Rückerl, Dominik ; Nagy, Gergely ; Kiss, Mate ; Peloquin, Matthew ; Budai, Marietta M. ; Cuaranta-Monroy, Ixchelt ; Simandi, Zoltan ; Steiner, Laszlo ; Nagy, Bela ; Poliska, Szilard ; Banko, Csaba ; Bacso, Zsolt ; Schulman, Ira G. ; Sauer, Sascha ; Deleuze, Jean-Francois ; Allen, Judith E. ; Benko, Szilvia ; Nagy, Laszlo (2018)
  • Publisher: Cell Press
  • Journal: Immunity, volume 48, issue 1, pages 75-90,000,000 (issn: 1074-7613, eissn: 1097-4180)
  • Related identifiers: doi: 10.1016/j.immuni.2017.12.010, pmc: PMC5772169
  • Subject: Elméleti orvostudományok | alternative macrophage polarization | Orvostudományok | transcription | STAT6 | Article | inflammasome activation | pyroptosis | macrophage epigenomics | IL-1β | inflammation | Technology Platforms | repression | IL-4

Summary The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL-4-activated STAT6 transcrip... View more