The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages

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Czimmerer, Z.; Daniel, B.; Horvath, A.; Rückerl, D.; Nagy, G.; Kiss, M.; Peloquin, M.; Budai, M.M.; Cuaranta-Monroy, I.; Simandi, Z.; Steiner, L.; Nagy, B.; Poliska, S.; Banko, C.; Bacso, Z.; Schulman, I.G.; Sauer, S.; Deleuze, J.F.; Allen, J.E.; Benko, S.; Nagy, L.;
  • Publisher: Cell Press
  • Journal: volume 48,issue 1,pages75-90,000,000issn: 1074-7613, eissn: 1097-4180
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  • Related identifiers: doi: 10.1016/j.immuni.2017.12.010, pmc: PMC5772169
  • Subject: alternative macrophage polarization | Elméleti orvostudományok | Orvostudományok | transcription | STAT6 | Article | inflammasome activation | pyroptosis | macrophage epigenomics | IL-1β | inflammation | Technology Platforms | repression | IL-4

Summary The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL-4-activated STAT6 transcrip... View more