Molecular Dynamics Investigation of Cl− and Water Transport through a Eukaryotic CLC Transporter
Article, Other literature type
Cheng, Mary Hongying
Coalson, Rob D.
- Publisher: The Biophysical Society
Channels and Transporters | Biophysics
Early crystal structures of prokaryotic CLC proteins identified three Cl– binding sites: internal (Sint), central (Scen), and external (Sext). A conserved external GLU (GLUex) residue acts as a gate competing for Sext. Recently, the first crystal structure of a eukaryot...