Molecular Dynamics Investigation of Cl− and Water Transport through a Eukaryotic CLC Transporter

Article, Other literature type English OPEN
Cheng, Mary Hongying ; Coalson, Rob D. (2012)
  • Publisher: The Biophysical Society
  • Journal: Biophysical Journal, volume 102, issue 6, pages 1,363-1,371 (issn: 0006-3495)
  • Related identifiers: pmc: PMC3309281, doi: 10.1016/j.bpj.2012.01.056
  • Subject: Channels and Transporters | Biophysics

Early crystal structures of prokaryotic CLC proteins identified three Cl– binding sites: internal (Sint), central (Scen), and external (Sext). A conserved external GLU (GLUex) residue acts as a gate competing for Sext. Recently, the first crystal structure of a eukaryot... View more
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