The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.

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Hackler, László; Ózsvári, Béla; Gyuris, Márió; Sipos, Péter; Fábián, Gabriella; Molnár, Eszter; Marton, Annamária; Faragó, Nóra; Mihály, József; Nagy, Lajos István; Szénási, Tibor; Diron, Andrea; Párducz, Árpád; Kanizsai, Iván; Puskás, László G.;
(2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 11,issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4778904, doi: 10.1371/journal.pone.0149832
  • Subject: Cultured Tumor Cells | Glioblastoma Multiforme | Cancer Treatment | Animal Models | Research Article | Apoptosis | Blastomas | Drosophila Melanogaster | Glioma Cells | Cell Processes | Oncology | Kinase Inhibitors | Cancers and Neoplasms | Animals | Glioblastoma Cells | Neurology | Neurological Tumors | Biology and Life Sciences | Cell Death | Research and Analysis Methods | Arthropoda | Medicine | Insects | Enzymology | Q | R | Cell Biology | Model Organisms | Drosophila | Biological Cultures | Biochemistry | Science | Organisms | Glioma | Cell Cultures | Medicine and Health Sciences | Enzyme Inhibitors | Invertebrates

C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 was mediated by affecting multiple targets as confirmed at transcription and protein ... View more
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