Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis

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Chou, En-Ju; Hung, Liang-Yi; Tang, Chieh-Ju C.; Hsu, Wen-Bin; Wu, Hsin-Yi; Liao, Pao-Chi; Tang, Tang K.;

CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonge... View more
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