publication . Article . Review . 2009

Human Splicing Finder: an online bioinformatics tool to predict splicing signals

Desmet, F.-O.; Hamroun, D.; Lalande, M.; Collod-Beroud, G.; Claustres, M.; Beroud, C.;
Open Access English
  • Published: 01 May 2009 Journal: NUCLEIC ACIDS RESEARCH, volume 37, issue 9, pages e67-e67 (issn: 0305-1048, eissn: 1362-4962, Copyright policy)
  • Publisher: OXFORD UNIV PRESS
Abstract
International audience; Thousands of mutations are identified yearly. Although many directly affect protein expression, an increasing proportion of mutations is now believed to influence mRNA splicing. They mostly affect existing splice sites, but synonymous, non-synonymous or nonsense mutations can also create or disrupt splice sites or auxiliary cis-splicing sequences. To facilitate the analysis of the different mutations, we designed Human Splicing Finder (HSF), a tool to predict the effects of mutations on splicing signals or to identify splicing motifs in any human sequence. It contains all available matrices for auxiliary sequence prediction as well as new...
Subjects
free text keywords: Methods Online, [SDV.GEN]Life Sciences [q-bio]/Genetics
Related Organizations
Funded by
EC| GEN2PHEN
Project
GEN2PHEN
Genotype-To-Phenotype Databases: A Holistic Solution
  • Funder: European Commission (EC)
  • Project Code: 200754
  • Funding stream: FP7 | SP1 | HEALTH
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publication . Article . Review . 2009

Human Splicing Finder: an online bioinformatics tool to predict splicing signals

Desmet, F.-O.; Hamroun, D.; Lalande, M.; Collod-Beroud, G.; Claustres, M.; Beroud, C.;