Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display
Article, Other literature type
Nelson, Kathryn M.
Grimes, Kimberly D.
Aldrich, Courtney C.
- Publisher: Elsevier BV
Chemistry & Biology,
Molecular Biology | Drug Discovery | Biochemistry | Pharmacology | Molecular Medicine | Clinical Biochemistry | Article
The adenylation (A) domains of nonribosomal peptide synthetases (NRPSs) activate aryl acids or amino acids to launch their transfer through the NRPS assembly line for the biosynthesis of many medicinally important natural products. In order to expand the substrate pool ...