Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display

Article, Other literature type English OPEN
Zhang, Keya ; Nelson, Kathryn M. ; Bhuripanyo, Karan ; Grimes, Kimberly D. ; Zhao, Bo ; Aldrich, Courtney C. ; Yin, Jun (2013)
  • Publisher: Elsevier BV
  • Journal: Chemistry & Biology, volume 20, issue 1, pages 92-101 (issn: 1074-5521)
  • Related identifiers: pmc: PMC3807743, doi: 10.1016/j.chembiol.2012.10.020
  • Subject: Molecular Biology | Drug Discovery | Biochemistry | Pharmacology | Molecular Medicine | Clinical Biochemistry | Article

The adenylation (A) domains of nonribosomal peptide synthetases (NRPSs) activate aryl acids or amino acids to launch their transfer through the NRPS assembly line for the biosynthesis of many medicinally important natural products. In order to expand the substrate pool ... View more
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