Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

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Takai, K ; Le, A ; Weaver, VM ; Werb, Z (2016)
  • Publisher: eScholarship, University of California
  • Journal: volume 7, issue 50, pages 82,889-82,901 (eissn: 1949-2553)
  • Related identifiers: doi: 10.18632/oncotarget.12658, pmc: PMC5341254
  • Subject: cancer-associated fibroblast | transforming growth factor-beta | triple-negative breast cancer | pirfenidone | transforming growth factor-β | fibrosis | Research Paper

Increased collagen expression in tumors is associated with increased risk of metastasis, and triple-negative breast cancer (TNBC) has the highest propensity to develop distant metastases when there is evidence of central fibrosis. Transforming growth factor-β (TGF-β) li... View more