Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

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Takai, K; Le, A; Weaver, VM; Werb, Z;

Increased collagen expression in tumors is associated with increased risk of metastasis, and triple-negative breast cancer (TNBC) has the highest propensity to develop distant metastases when there is evidence of central fibrosis. Transforming growth factor-β (TGF-β) li... View more