Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer
- Publisher: eScholarship, University of California
cancer-associated fibroblast | transforming growth factor-beta | triple-negative breast cancer | pirfenidone | transforming growth factor-β | fibrosis | Research Paper
Increased collagen expression in tumors is associated with increased risk of metastasis, and triple-negative breast cancer (TNBC) has the highest propensity to develop distant metastases when there is evidence of central fibrosis. Transforming growth factor-β (TGF-β) li...