publication . Article . 2018

Exploring the Immunomodulatory Moonlighting Activities of Acute Phase Proteins for Tolerogenic Dendritic Cell Generation

Inmaculada Serrano; Ana Luque; Josep M. Aran;
Open Access English
  • Published: 01 Apr 2018 Journal: Frontiers in Immunology, volume 9 (issn: 1664-3224, eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
The acute phase response is generated by an overwhelming immune-inflammatory process against infection or tissue damage, and represents the initial response of the organism in an attempt to return to homeostasis. It is mediated by acute phase proteins (APPs), an assortment of highly conserved plasma reactants of seemingly different functions that, however, share a common protective role from injury. Recent studies have suggested a crosstalk between several APPs and the mononuclear phagocyte system (MPS) in the resolution of inflammation, to restore tissue integrity and function. In fact, monocyte-derived dendritic cells (Mo-DCs), an integral component of the MPS...
Subjects
free text keywords: acute phase proteins, RC581-607, inflammation, Review, immunotherapy, Immunologic diseases. Allergy, monocyte-derived dendritic cells, Immunology, tolerance
157 references, page 1 of 11

1 Ortega-Gómez A Perretti M Soehnlein O Resolution of inflammation: an integrated view. EMBO Mol Med (2003) 5(5):661–74.10.1002/emmm.201202382 [OpenAIRE] [DOI]

2 Jakubzick CV Randolph GJ Henson PM. Monocyte differentiation and antigen-presenting functions. Nat Rev Immunol (2017) 17(6):349–62.10.1038/nri.2017.28 28436425 [PubMed] [DOI]

3 Banchereau J Steinman RM. Dendritic cells and the control of immunity. Nature (1998) 392(6673):245–52.10.1038/32588 9521319 [PubMed] [DOI]

4 Bancherau J Paczesny S Blanco P Bennet L Pascual V Fay J Dendritic cells: controllers of the immune system and a new promise for immunotherapy. Ann N Y Acad Sci (2003) 987:180–7.10.1111/j.1749-6632.2003.tb06047.x 12727638 [PubMed] [DOI]

5 Macagno A Napolitani G Lanzavecchia A Sallusto F. Duration, combination and timing: the signal integration model of dendritic cell activation. Trends Immunol (2007) 28(5):227–33.10.1016/j.it.2007.03.008 17403614 [PubMed] [DOI]

6 Gregori S. Dendritic cells in networks of immunological tolerance. Tissue Antigens (2011) 77(4):89–99.10.1111/j.1399-0039.2010.01615.x 21214520 [PubMed] [DOI]

7 Whicher JT Westacott CI The acute phase response. In: Whicher JT Evans SW, editors. Biochemistry of Inflammation Boston: Kluwer Academic Publishers (1992). vol. 18, p. 243–69.

8 Ebersole JL Cappelli D Acute-phase reactants in infections and inflammatory diseases. Periodontol 2000 (2000) 23(1):19–49.10.1034/j.1600-0757.2000.2230103.x 11276764 [PubMed] [DOI]

9 Cripse IN. Hepatocytes as immunological agents. J Immunol (2016) 196(1):17–21.10.4049/jimmunol.1501668 26685314 [OpenAIRE] [PubMed] [DOI]

10 Gabay C Kushner I Acute-phase proteins and other systemic responses to inflammation. N Engl J Med (1999) 340(6):448–54.10.1056/NEJM199902113400607 9971870 [PubMed] [DOI]

11 Parrow NL Fleming RE Minnick MF. Sequestration and scavenging of iron in infection. Infect Immun (2013) 81(10):3503–14.10.1128/IAI.00602-13 23836822 [OpenAIRE] [PubMed] [DOI]

12 Baumann H Gauldie J. The acute phase response. Immunol Today (1994) 15(2):74–80.10.1016/0167-5699(94)90137-6 7512342 [PubMed] [DOI]

13 Chrousos GP The hypothalamic-pituitary-adrenal axis and the immune-mediated inflammation. N Engl J Med (1995) 332(20):1351–62.10.1056/NEJM199505183322008 7715646 [PubMed] [DOI]

14 Schrödl W Büchler R Wendler S Reinhold P Muckova P Reindl J Acute phase proteins as promising biomarkers: perspectives and limitation for human veterinary medicine. Proteomics Clin Appl (2016) 10(11):1077–92.10.1002/prca.201600028 27274000 [PubMed] [DOI]

15 Sprague AH Khalil RA Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol (2009) 78(6):539–52.10.1016/j.bcp.2009.04.029 19413999 [OpenAIRE] [PubMed] [DOI]

157 references, page 1 of 11
Abstract
The acute phase response is generated by an overwhelming immune-inflammatory process against infection or tissue damage, and represents the initial response of the organism in an attempt to return to homeostasis. It is mediated by acute phase proteins (APPs), an assortment of highly conserved plasma reactants of seemingly different functions that, however, share a common protective role from injury. Recent studies have suggested a crosstalk between several APPs and the mononuclear phagocyte system (MPS) in the resolution of inflammation, to restore tissue integrity and function. In fact, monocyte-derived dendritic cells (Mo-DCs), an integral component of the MPS...
Subjects
free text keywords: acute phase proteins, RC581-607, inflammation, Review, immunotherapy, Immunologic diseases. Allergy, monocyte-derived dendritic cells, Immunology, tolerance
157 references, page 1 of 11

1 Ortega-Gómez A Perretti M Soehnlein O Resolution of inflammation: an integrated view. EMBO Mol Med (2003) 5(5):661–74.10.1002/emmm.201202382 [OpenAIRE] [DOI]

2 Jakubzick CV Randolph GJ Henson PM. Monocyte differentiation and antigen-presenting functions. Nat Rev Immunol (2017) 17(6):349–62.10.1038/nri.2017.28 28436425 [PubMed] [DOI]

3 Banchereau J Steinman RM. Dendritic cells and the control of immunity. Nature (1998) 392(6673):245–52.10.1038/32588 9521319 [PubMed] [DOI]

4 Bancherau J Paczesny S Blanco P Bennet L Pascual V Fay J Dendritic cells: controllers of the immune system and a new promise for immunotherapy. Ann N Y Acad Sci (2003) 987:180–7.10.1111/j.1749-6632.2003.tb06047.x 12727638 [PubMed] [DOI]

5 Macagno A Napolitani G Lanzavecchia A Sallusto F. Duration, combination and timing: the signal integration model of dendritic cell activation. Trends Immunol (2007) 28(5):227–33.10.1016/j.it.2007.03.008 17403614 [PubMed] [DOI]

6 Gregori S. Dendritic cells in networks of immunological tolerance. Tissue Antigens (2011) 77(4):89–99.10.1111/j.1399-0039.2010.01615.x 21214520 [PubMed] [DOI]

7 Whicher JT Westacott CI The acute phase response. In: Whicher JT Evans SW, editors. Biochemistry of Inflammation Boston: Kluwer Academic Publishers (1992). vol. 18, p. 243–69.

8 Ebersole JL Cappelli D Acute-phase reactants in infections and inflammatory diseases. Periodontol 2000 (2000) 23(1):19–49.10.1034/j.1600-0757.2000.2230103.x 11276764 [PubMed] [DOI]

9 Cripse IN. Hepatocytes as immunological agents. J Immunol (2016) 196(1):17–21.10.4049/jimmunol.1501668 26685314 [OpenAIRE] [PubMed] [DOI]

10 Gabay C Kushner I Acute-phase proteins and other systemic responses to inflammation. N Engl J Med (1999) 340(6):448–54.10.1056/NEJM199902113400607 9971870 [PubMed] [DOI]

11 Parrow NL Fleming RE Minnick MF. Sequestration and scavenging of iron in infection. Infect Immun (2013) 81(10):3503–14.10.1128/IAI.00602-13 23836822 [OpenAIRE] [PubMed] [DOI]

12 Baumann H Gauldie J. The acute phase response. Immunol Today (1994) 15(2):74–80.10.1016/0167-5699(94)90137-6 7512342 [PubMed] [DOI]

13 Chrousos GP The hypothalamic-pituitary-adrenal axis and the immune-mediated inflammation. N Engl J Med (1995) 332(20):1351–62.10.1056/NEJM199505183322008 7715646 [PubMed] [DOI]

14 Schrödl W Büchler R Wendler S Reinhold P Muckova P Reindl J Acute phase proteins as promising biomarkers: perspectives and limitation for human veterinary medicine. Proteomics Clin Appl (2016) 10(11):1077–92.10.1002/prca.201600028 27274000 [PubMed] [DOI]

15 Sprague AH Khalil RA Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol (2009) 78(6):539–52.10.1016/j.bcp.2009.04.029 19413999 [OpenAIRE] [PubMed] [DOI]

157 references, page 1 of 11
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publication . Article . 2018

Exploring the Immunomodulatory Moonlighting Activities of Acute Phase Proteins for Tolerogenic Dendritic Cell Generation

Inmaculada Serrano; Ana Luque; Josep M. Aran;