Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

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Sandra M. McLachlan; Basil Rapoport;

Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A-subunit. In contrast... View more
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