Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

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McLachlan, Sandra M.; Rapoport, Basil;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Immunology,volume 8 (issn: 1664-3224, eissn: 1664-3224)
  • Related identifiers: doi: 10.3389/fimmu.2017.01845, doi: 10.3389/fimmu.2017.01845/full, pmc: PMC5742354
  • Subject: RC581-607 | thyrotropin receptor | intermolecular and intramolecular epitope spreading | thyroid peroxidase | Immunologic diseases. Allergy | thyroid autoantibodies | original antigenic sin | thyroglobulin | Review | Immunology | immunodominant region
    mesheuropmc: endocrine system | endocrine system diseases

Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A-subunit. In contrast... View more
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