Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations

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van Aelst, Kara ; Saikrishnan, Kayarat ; Szczelkun, Mark D (2015)
  • Publisher: Oxford University Press
  • Journal: volume 43, issue 21, pages 10,430-10,443 (issn: 0305-1048, eissn: 1362-4962)
  • Related identifiers: pmc: PMC4666363, doi: 10.1093/nar/gkv1129
  • Subject: /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 | Nucleic Acid Enzymes | Journal Article | Research Support, Non-U.S. Gov't

<p>The prokaryotic Type ISP restriction-modification enzymes are single-chain proteins comprising an Mrr-family nuclease, a superfamily 2 helicase-like ATPase, a coupler domain, a methyltransferase, and a DNA-recognition domain. Upon recognising an unmodified DNA target... View more
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