Targeting potassium channels for increasing delivery of imaging agents and therapeutics to brain tumors

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Khaitan, Divya; Ningaraj, Nagendra S.;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Pharmacology,volume 4 (issn: 1663-9812, eissn: 1663-9812)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3665941, doi: 10.3389/fphar.2013.00062, doi: 10.3389/fphar.2013.00062/full
  • Subject: drug delivery | Blood Brain-Tumor Barrier (BTB) | BTB Modulation Increases Drug Delivery to Brain Tumors Key Words: Blood Brain-Barrier (BBB) | blood–brain barrier | brain tumors | biochemical modulation of BTB | RM1-950 | Therapeutics. Pharmacology | potassium channels | Pharmacology | Original Research Article | DCE-MRI | blood–brain tumor barrier | metastatic brain tumor

Every year in the US, 20,000 new primary and nearly 200,000 metastatic brain tumor cases are reported. The cerebral microvessels/ capillaries that form the blood–brain barrier (BBB) not only protect the brain from toxic agents in the blood but also pose a significant hi... View more
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