Notch Signaling Activation in Human Embryonic Stem Cells Is Required for Embryonic, but Not Trophoblastic, Lineage Commitment

Article, Other literature type English OPEN
Yu, Xiaobing; Zou, Jizhong; Ye, Zhaohui; Hammond, Holly; Chen, Guibin; Tokunaga, Akinori; Mali, Prashant; Li, Yue-Ming; Civin, Curt; Gaiano, Nicholas; Cheng, Linzhao;
  • Publisher: Elsevier BV
  • Journal: Cell Stem Cell,volume 2,issue 5,pages461-471 (issn: 1934-5909)
  • Related identifiers: pmc: PMC2442567, doi: 10.1016/j.stem.2008.03.001
  • Subject: Genetics | Cell Biology | Molecular Medicine | Article
    mesheuropmc: reproductive and urinary physiology | biological phenomena, cell phenomena, and immunity

The Notch signaling pathway plays important roles in cell fate determination during embryonic development and adult life. In this study, we focus on the role of Notch signaling in governing cell fate choices in human embryonic stem (hES) cells. Using genetic and pharmac... View more
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