In-silico docking based design and synthesis of [1H,3H] imidazo[4,5-b] pyridines as lumazine synthase inhibitors for their effective antimicrobial activity

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Harer, Sunil L.; Bhatia, Manish S.;
  • Publisher: Wolters Kluwer Medknow Publications
  • Journal: Journal of Pharmacy and Bioallied Sciences,volume 6,issue 4,pages285-296 (issn: 0975-7406, eissn: 0976-4879)
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  • Related identifiers: pmc: PMC4231389, doi: 10.4103/0975-7406.142962
  • Subject: Original Article | Antimicrobial | lumazine synthase | QD71-142 | docking score | imidazopyridine | Analytical chemistry | Pharmacy and materia medica | minimum inhibitory concentration | RS1-441

Purpose: The imidazopyridine moiety is important pharmacophore that has proven to be useful for a number of biologically relevant targets, also reported to display antibacterial, antifungal, antiviral properties. Riboflavin biosynthesis involving catalytic step of Lumaz... View more
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