PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations

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Paschou, Peristera; Ziv, Elad; Burchard, Esteban G; Choudhry, Shweta; Rodriguez-Cintron, William; Mahoney, Michael W; Drineas, Petros;
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 3,issue 9 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: pmc: PMC1988848, doi: 10.1371/journal.pgen.0030160
  • Subject: QH426-470 | Genetics | Research Article | Computer Science | Genetics and Genomics | Homo (Human)

Existing methods to ascertain small sets of markers for the identification of human population structure require prior knowledge of individual ancestry. Based on Principal Components Analysis (PCA), and recent results in theoretical computer science, we present a novel ... View more
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