APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

Article English OPEN
Sando, Sigrid B; Melquist, Stacey; Cannon, Ashley; Hutton, Michael L; Sletvold, Olav; Saltvedt, Ingvild; White, Linda R; Lydersen, Stian; Aasly, Jan O;

<p>Abstract</p> <p>Background</p> <p>The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The <it>APOE </it>ε4 allele is the only consistently identified risk factor for late onset Alzheimer's ... View more
  • References (37)
    37 references, page 1 of 4

    Mahley RW: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988, 240(4852):622-630.

    Zannis VI, Breslow JL: Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry 1981, 20(4):1033-1041.

    3. Gerdes LU, Klausen IC, Sihm I, Faergeman O: Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet Epidemiol 1992, 9(3):155-167.

    4. Corbo RM, Scacchi R: Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele? Ann Hum Genet 1999, 63(Pt 4):301-310.

    5. Singh PP, Singh M, Mastana SS: APOE distribution in world populations with new data from India and the UK. Ann Hum Biol 2006, 33(3):279-308.

    6. Gerdes LU, Gerdes C, Hansen PS, Klausen IC, Faergeman O, Dyerberg J: The apolipoprotein E polymorphism in Greenland Inuit in its global perspective. Hum Genet 1996, 98(5):546-550.

    7. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD: Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 1993, 90(5):1977-1981.

    8. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ: Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993, 43(8):1467-1472.

    9. Okuizumi K, Onodera O, Tanaka H, Kobayashi H, Tsuji S, Takahashi H, Oyanagi K, Seki K, Tanaka M, Naruse S: ApoE-epsilon 4 and early-onset Alzheimer's. Nat Genet 1994, 7(1):10-11.

    10. van Duijn CM, de Knijff P, Cruts M, Wehnert A, Havekes LM, Hofman A, Van Broeckhoven C: Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet 1994, 7(1):74-78.

  • Similar Research Results (1)
  • Related Organizations (1)
  • Metrics
Share - Bookmark