Mapping challenging mutations by whole-genome sequencing

Article, Preprint English OPEN
Fabritius, Amy; Golden, Andy; Smith, Harold; Jaramillo-Lambert, Aimee;
  • Publisher: Genetics Society of America
  • Journal: G3: Genes|Genomes|Genetics,volume 6,issue 5,pages1,297-1,304 (issn: 2160-1836, eissn: 2160-1836)
  • Related identifiers: doi: 10.1101/036046, doi: 10.1534/g3.116.028316, pmc: PMC4856081
  • Subject: bepress|Life Sciences|Biology | QH426-470 | Genetics | variant detection | bepress|Life Sciences|Genetics and Genomics|Genetics | complex alleles | Investigations | forward genetics | SNP mapping

Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists of monogenic, r... View more
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