Mapping Challenging Mutations by Whole-Genome Sequencing

Article, Preprint English OPEN
Harold E. Smith ; Amy S. Fabritius ; Aimee Jaramillo-Lambert ; Andy Golden (2016)
  • Publisher: Genetics Society of America
  • Journal: G3: Genes, volume 6, issue 5, pages 1,297-1,304 (issn: 2160-1836, eissn: 2160-1836)
  • Related identifiers: doi: 10.1101/036046, doi: 10.1534/g3.116.028316, pmc: PMC4856081
  • Subject: bepress|Life Sciences|Biology | QH426-470 | Genetics | variant detection | bepress|Life Sciences|Genetics and Genomics|Genetics | complex alleles | Investigations | forward genetics | SNP mapping

Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists of monogenic, r... View more
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