Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Article English OPEN
Shiva Marthandan ; Uwe Menzel ; Steffen Priebe ; Marco Groth ; Reinhard Guthke ; Matthias Platzer ; Peter Hemmerich ; Christoph Kaether ; Stephan Diekmann
  • Publisher: BMC
  • Journal: Biological Research, volume 49 (issn: 0716-9760, eissn: 0717-6287)
  • Related identifiers: doi: 10.1186/s40659-016-0095-2, pmc: PMC4963952
  • Subject: Senescence | Agricultural and Biological Sciences(all) | Fibroblasts | Biochemistry, Genetics and Molecular Biology(all) | Research Article | Medicine(all) | Aging | Transcriptome analysis | DNA repair | Biology (General) | γ-irradiation | QH301-705.5

Background Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can result in senescence indu... View more
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