Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy

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Oelkrug, Rebecca; Herrmann, Beate; Geissler, Cathleen; Harder, Lisbeth; Koch, Christiane; Lehnert, Hendrik; Oster, Henrik; Kirchner, Henriette; Mittag, Jens;
  • Publisher: Elsevier
  • Journal: Molecular Metabolism,volume 6,issue 10,pages1,126-1,136 (issn: 2212-8778, eissn: 2212-8778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.molmet.2017.06.016, pmc: PMC5641602
  • Subject: HPRT, hypoxanthine-guanine phosphoribosyltransferase | GH, growth hormone | IUGR, intrauterine growth restriction | Pregnancy | Cyclo, cyclophilin D | DNP, 2,4-dinitrophenol | Internal medicine | Fever | GHR, growth hormone receptor | UCP1, uncoupling protein 1 | Original Article | Thermogenesis | Brown fat | IGF-1, insulin-like growth factor 1 | gWAT, gonadal white adipose tissue | iWAT, inguinal white adipose tissue | RC31-1245 | IGF-1 | Insulin resistance | iBAT, interscapular brown adipose tissue

Objective: Maternal and environmental factors control the epigenetic fetal programming of the embryo, thereby defining the susceptibility for metabolic or endocrine disorders in the offspring. Pharmacological interventions required as a consequence of gestational proble... View more
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