Etude rétrospective de l'influence des polymorphismes génétiques de CYP3A4, CYP3A5 et ABCB1 des donneurs et des receveurs sur les effets des immunosuppresseurs en transplantation hépatique

Doctoral thesis French OPEN
Gratien-Debette , Marilyne;
(2015)
  • Publisher: HAL CCSD
  • Subject: CYP3A5 | Graft loss | Transplantation hépatique | CYP3A4*22 | Perte du greffon | Chronic rejection | Néphrotoxicité | Nephrotoxicity | ABCB1 | Rejet chronique | [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology | [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology | Liver transplantation

Liver transplantation is now a well mastered surgery with standardized procedures, but the long-term clinical outcomes of the graft and the patient remain uncertain. The pharmacogenetic study of the calcineurin inhibitors (CNI) cyclosporine and tacrolimus should help to... View more
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