Molecular and Structural Characterization of the Tegumental 20.6-kDa Protein in Clonorchis sinensis as a Potential Druggable Target

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Yu-Jung Kim ; Won Gi Yoo ; Myoung-Ro Lee ; Jung-Mi Kang ; Byoung-Kuk Na ; Shin-Hyeong Cho ; Mi-Yeoun Park ; Jung-Won Ju (2017)
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences, volume 18, issue 3 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: pmc: PMC5372573, doi: 10.3390/ijms18030557
  • Subject: homology modelling | localization | Chemistry | virtual screening | Clonorchis sinensis | Clonorchis sinensis; tegument; homology modelling; I-TASSER; structure; localization; virtual screening; docking; compound | QD1-999 | I-TASSER | compound | Article | structure | QH301-705.5 | docking | tegument | Biology (General)

The tegument, representing the membrane-bound outer surface of platyhelminth parasites, plays an important role for the regulation of the host immune response and parasite survival. A comprehensive understanding of tegumental proteins can provide drug candidates for use... View more
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